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Drug Resistant Bacteria

by coldwarrior ( 112 Comments › )
Filed under Academia, Medicine, Open thread, saturday lecture series, Science at May 8th, 2012 - 3:00 pm

Antibiotics work because they target bacteria. Antibiotics do not work on viruses, hence the reason they are useless on the common cold. Most antibiotics work by disrupting one of the many steps in protein synthesis in a cell. They may work at ‘S’ in the cell cycle where DNA replication occurs or they will disrupt the cell wall causing cell failure. So, rapidly multiplying cells like bacteria are killed as fast as they can replicate which helps your body overcome the infection by reducing the bacterial load. In the perfect world, this gets rid of the infecting bacteria.

 

The perfect world is a great place, and it does not exist. The fact is that the bacteria are smart little guys and can figure out how to beat these antibiotics. All it takes is for one cell to develop a counter to the mechanism by which the antibiotics work and it off to the evolutionary races. It works like this: you have 100 bacteria, you introduce some antibiotics, all of the bacteria die off except 2. These two then go on to multiply and thereby replicate the antibiotic resistance render that drug mostly useless. Did you ever see the commercial for the hand sanitizers or Lysol? 99% of germs killed! Yeah, well the 1% that lived can now take a jacuzzi  in your hand sanitizer while drinking Lysol cocktails at happy hour, so make sure you don’t ingest them! Same thing happens with antibiotics. Overuse and misuse creates these new strains of multi-drug resistant bacteria like MRSA and VRE.

 

Misuse means taking the antibiotic until you don’t feel like taking it anymore…Oh, I feel better, I don’t need to take the rest of this. Combine Misuse with Overuse which is the  prescribing of antibiotics for virus infections or because the patient insists on them is just as advantageous to the bacteria that can survive the antibiotic.

 

So, with the background out of the way, lets scale this up a bit and take a huge developing country that makes these antibiotics, combine that with a little underdevelopment, some bad water, and less than sanitary conditions, and massive overuse and misuse of antibiotics and VIOLA! You have a multi-drug resistant bacteria bomb just waiting to go off.

 

The article below is long and very detailed. I assure you that if you are not familiar with this topic please take the time and read it. These infections are just one airplane flight away from your house. Proper hand washing is the single best disruptor of the infection cycle, so wash your hands with regular soap and warm water often. Enjoy the rest of your day.

 

Drug-Defying Germs From India Speed Post-Antibiotic Era

By Jason Gale and Adi Narayan – May 7, 2012
Bloomberg Markets Magazine

Lill-Karin Skaret, a 67-year-old grandmother from Namsos, Norway, was traveling to a lakeside vacation villa near India’s port city of Kochi in March 2010 when her car collided with a truck. She was rushed to the Amrita Institute of Medical Sciences, her right leg broken and her artificial hip so damaged that replacing it required 12 hours of surgery.

Three weeks later and walking with the aid of crutches, Skaret was relieved to be home. Then her doctor gave her upsetting news. Mutant germs that most antibiotics can’t kill had entered her bladder, probably from a contaminated hospital catheter in India. She risked a life-threatening infection if the bacteria invaded her bloodstream — a waiting game over which she had limited control, Bloomberg Markets magazine reports in its June issue.

“I got a call from my doctor who told me they found this bug in me and I had to take precautions,” Skaret remembers. “I was very afraid.”

Skaret was lucky. Eventually, her body rid itself of the bacteria, and she escaped harm from a new type of superbug that scientists warn is spreading faster, further and in more alarming ways than any they’ve encountered. Researchers say the epicenter is India, where drugs created to fight disease have taken a perverse turn by making many ailments harder to treat.

India’s $12.4 billion pharmaceutical industry manufactures almost a third of the world’s antibiotics, and people use them so liberally that relatively benign and beneficial bacteria are becoming drug immune in a pool of resistance that thwarts even high-powered antibiotics, the so-called remedies of last resort.

Medical Tourism

Poor hygiene has spread resistant germs into India’s drains, sewers and drinking water, putting millions at risk of drug-defying infections. Antibiotic residues from drug manufacturing, livestock treatment and medical waste have entered water and sanitation systems, exacerbating the problem.

As the superbacteria take up residence in hospitals, they’re compromising patient care and tarnishing India’s image as a medical tourism destination.

“There isn’t anything you could take with you traveling that would be useful against these superbugs,” says Robert Moellering Jr., a professor of medical research at Harvard Medical School in Boston.

The germs — and the gene that confers their heightened powers — are jumping beyond India. More than 40 countries have discovered the genetically altered superbugs in blood, urine and other patient specimens. Canada, France, Italy, Kosovo and South Africa have found them in people with no travel links, suggesting the bugs have taken hold there.

Post-Antibiotic Era

Drug resistance of all sorts is bringing the planet closer to what the World Health Organization calls a post-antibiotic era.

“Things as common as strep throat or a child’s scratched knee could once again kill,” WHO Director-General Margaret Chan said at a March medical meeting in Copenhagen. “Hip replacements, organ transplants, cancer chemotherapy and care of preterm infants would become far more difficult or even too dangerous to undertake.”

Already, current varieties of resistant bacteria kill more than 25,000 people in Europe annually, the WHO said in March. The toll means at least 1.5 billion euros ($2 billion) in extra medical costs and productivity losses each year.

“If this latest bug becomes entrenched in our hospitals, there is really nothing we can turn to,” says Donald E. Low, head of Ontario’s public health lab in Toronto. “Its potential is to be probably greater than any other organism.”

Promiscuous Plasmids

The new superbugs are multiplying so successfully because of a gene dubbed NDM-1. That’s short for New Delhi metallo-beta- lactamase-1, a reference to the city where a Swedish man was hospitalized in 2007 with an infection that resisted standard antibiotic treatments.

The superbugs are proving to be not only wily but also highly sexed. The NDM-1 gene is carried on mobile loops of DNA called plasmids that transfer easily among and across many types of bacteria through a form of microbial mating. This means that unlike previous germ-altering genes, NDM-1 can infiltrate dozens of bacterial species. Intestine-dwelling E. coli, the most common bacterium that people encounter, soil-inhabiting microbes and water-loving cholera bugs can all be fortified by the gene.

What’s worse, germs empowered by NDM-1 can muster as many as nine other ways to destroy the world’s most potent antibiotics.

Untreatable Killers

NDM-1 is changing common bugs that drugs once easily defeated into untreatable killers, says Timothy Walsh, a professor of medical microbiology at Cardiff University in Wales. Or as in Skaret’s case, the gene is creating silent stowaways poised to attack if they find a weakness — or that can pass harmlessly when the body’s conventional microbes win out.

Cancer patients whose chemotherapy inadvertently ulcerates their gastrointestinal tract are especially vulnerable, says Lindsay Grayson, director of infectious diseases and microbiology at Melbourne’s Austin Hospital.

“These bugs go straight into their bloodstream,” Grayson says. Newborns, transplant recipients and people with compromised immune systems are at higher risk, he says.

Six infants died in a small hospital in Bijnor in northern India from April 2009 to August 2010 after NDM-1-containing bacteria resisted all commonly used antibiotics.

India Vulnerable

India is susceptible because it has many sick people to begin with. The country accounts for more than a quarter of the world’s pneumonia cases. It has the most tuberculosis patients globally and Asia’s highest incidence of cholera.

Most of India’s 5,000-plus drugmakers produce low-cost generic antibiotics, letting users and doctors switch around to find ones that work. While that’s happening, the germs the antibiotics are targeting accumulate genes for evading each drug. That enables the bugs to survive and proliferate whenever they encounter an antibiotic they’ve already adapted to.

India’s inadequate sanitation increases the scope of antibacterial resistance. More than half of the nation’s 1.2 billion residents defecate in the open, and 23 percent of city dwellers have no toilets, according to a 2012 report by the WHO and Unicef.

Uncovered sewers and overflowing drains in even such modern cities as New Delhi spread resistant germs through feces, tainting food and water and covering surfaces in what Dartmouth Medical School researcher Elmer Pfefferkorn describes as a fecal veneer.

Tap Water

Germs with the NDM-1 gene existed in 51 of 171 open drains along the capital’s streets and in two of 50 samples of public tap water, Walsh found in 2010.

Abdul Ghafur, an infectious diseases doctor in Chennai, southern India’s largest city, sees patients every week who suffer from multidrug-resistant infections. He and others who used to successfully combat infections with such common antibiotics as amoxicillin now must use more-expensive ones that target a broader range of germs but typically cause greater side effects. Some infections don’t respond to any treatment, evading all antibiotics, he says.

That’s bad news because the more frequently the NDM-1 gene is inserted into different bacteria, the more likely it will enter virulent forms of E. coli, sparking outbreaks that may be impossible to subdue, says David Livermore, who heads antibiotic resistance monitoring at the U.K.’s Health Protection Agency in London.

Black Death

The gene may even spread to the microbial cause of bubonic plague, the medieval scourge known as Black Death that still persists in pockets of the globe.

“It’s a matter of time and chance,” says Mark Toleman, a molecular geneticist at Cardiff University. Plasmids carrying the NDM-1 gene can easily be inserted into the genetic material of Yersinia pestis, the cause of plague, making the infection harder to treat, Toleman says.

“There is a tsunami that’s going to happen in the next year or two when antibiotic resistance explodes,” says Ghafur, 40, seated at a polished wooden table in a consulting room in Chennai as patients fill 20 metal chairs in the waiting area, forcing others into the corridor. “We need wartime measures to deal with this now.”

R.K. Srivastava, India’s former director general of health services, says the government is giving top priority to antimicrobial resistance, including increasing surveillance of hospitals’ antibiotics use.

Name Shame

At the same time, it’s trying to preserve the country’s health-tourism industry. Bristling that foreigners coined a name that singles out their capital to describe an emerging health nightmare, officials say the world is picking on India for troubles that impede all developing nations.

When Indian researchers joined international teams studying the NDM-1 gene, the government questioned the data and methods of the scientists, among them Chennai microbiologist Karthikeyan K. Kumarasamy.

“These bacteria were present globally,” says Nirmal K. Ganguly, a former director general of the Indian Council of Medical Research and one of 13 members of a government task force created in September 2010 to respond to the NDM-1 threat.

“When you are blamed, the only reaction is that you put your back to the wall and fight.”

Ulterior Motive?

S.S. Ahluwalia, a former deputy opposition leader in the upper house of India’s parliament and a member of the Bharatiya Janata Party, says Western rivals want to muscle in on the medical tourism industry. Josef Woodman, founder of the guidebook “Patients Beyond Borders,” values the industry globally at $54 billion a year.

“These reports are meant to destabilize India’s emergence as a health destination,” says Ahluwalia, whose term ended in April.

About 850,000 medical tourists traveled to India in 2010 for treatments from lifesaving cancer operations to cosmetic surgeries, generating $872 million in revenue, according to the Associated Chambers of Commerce and Industry of India, or Assocham. The number of foreign patients is predicted to almost quadruple by 2015, the trade body says.

Manish Kakkar, a doctor researching infectious diseases at the New Delhi-based Public Health Foundation of India and a task force member, says the government has its priorities wrong.

“We have been in a phase of denial,” he says. “Rather than responding to the situation scientifically, we’ve completely diverted attention, saying that it’s attacking our medical tourism.”

‘That’s What’s Scary’

Kakkar and others worry about NDM-1 because unlike germs such as VRE, short for the vancomycin-resistant enterococci bug that can cause infection around a patient’s surgical incision, NDM-1 is spreading beyond hospitals.

Two travelers from the Netherlands picked up an NDM-1 bug in their bowels after visiting India in 2009 although they hadn’t received medical care there, says Maurine Leverstein-van Hall, a clinical microbiologist at the University Medical Center in the Dutch city of Utrecht.

“That’s what’s scary,” she says. “It’s not just surgery or being near a hospital. In some way, you get it through the food chain or through the water.”

For now, it’s impossible to tell how common NDM-1 infections are or how often the mutant germs kill because testing and surveillance are inadequate in developing countries, says Keith Klugman, the William H. Foege chair of global health at Emory University’s Rollins School of Public Health in Atlanta.

‘Perfect Breeding Ground’

Cardiff’s Walsh estimates 100 million Indians carry germs that harbor the NDM-1 gene, based on an extrapolation of studies in New Delhi and from neighboring Pakistan.

“It’s not measured, and that’s the problem,” says Klugman, who pinpoints India as the epicenter.

India’s jammed cities, poor sanitation and abundant antibiotics produce an ideal incubator, Harvard’s Moellering says.

“You have almost no control over the prescription of antibiotics,” says Moellering, who has studied drug resistance for four decades. “You have horrible sanitation problems in many parts of the country. You have incredible poverty, and you have crowding. When you put those four things together, it’s the perfect breeding ground for multidrug-resistant bacteria.”

Antibiotics even pollute India’s rivers, streams and soil. The bacteria that thrive in these places do so because they’ve developed resistance to the drugs they encounter. People or animals who ingest the water or soil may become colonized by the resistant germs.

Mining Cipro

Until the government built a pipeline to a modern sewage plant in 2010, the Patancheru Enviro Tech Ltd. treatment facility on some days released the equivalent of 45,000 daily doses of ciprofloxacin into the Isakavagu stream outside Hyderabad in southern India, Swedish researchers reported in 2007. The plant treated wastewater from drug-making factories.

Residue from ciprofloxacin, a mainstay treatment for E. coli infections, was so prevalent in river sediment downstream that lead researcher Joakim Larsson of the University of Gothenburg jokes, “Had ciprofloxacin been a little bit more expensive, we could probably mine it from the ground.”

India’s antibiotics overload is forcing doctors to rely on ever-more-powerful drugs. Many now turn to a class called penicillin-based carbapenems to treat ailments as routine as urinary tract infections, says Grayson, who was editor-in-chief of medical text “Kucer’s The Use of Antibiotics” (Hodder Arnold/ASM Press, 2010).

‘Antibiotic Stewardship’

NDM-1 has rendered even carbapenems useless, sometimes leaving no way to fight infections. Two drugs potentially capable of treating NDM-1 bacteria have toxic side effects in some patients that include an increased risk of death.

“It’s an example of why we need to have good surveillance and why we need to have good antibiotic stewardship,” says Thomas R. Frieden, director of the U.S. Centers for Disease Control and Prevention in Atlanta. “We are looking at the specter of untreatable illness.”

Drugmakers have been slow to respond with new medicines. Most abandoned antibiotic discovery during the past decade, says Karen Bush, a microbiologist at Indiana University in Bloomington. She led teams that developed five bacteria-fighting drugs beginning in the 1970s in laboratories that are now part of AstraZeneca Plc (AZN), Bristol-Myers Squibb Co. (BMY), Johnson & Johnson and Pfizer Inc. (PFE)

Companies instead pursued hypertension and high-cholesterol drugs that patients take for a lifetime rather than a few weeks, she says.

International Uproar

Kumarasamy, the Chennai microbiologist, says he thought he was doing his country a favor when he helped track down the cause of unexplained deaths inside India. Instead, he sparked an international uproar over NDM-1.

Beginning in June 2000, Kumarasamy, now 36, studied bacteria and went from hospital to hospital in Chennai to collect specimens. He says he witnessed a steady increase in difficult-to-treat infections. Patients were dying, and doctors couldn’t identify what type of resistant germs killed them, he says.

“No matter how skilled or intelligent the doctor is, they are helpless when it comes to these infections,” he says over lunch of rice and curry in a noisy Chennai food court. He didn’t keep a tally of the deaths.

Kumarasamy, who received a Bachelor of Science degree from Navarasam Arts & Science College in Tamil Nadu state in 1997, says he began isolating bacteria from the blood, sputum, pus and urine of patients and freezing the samples. He quit his lab job in 2007 to study resistant germs for a doctorate in microbiology at the University of Madras. He’s winding up his thesis on carbapenem-resistant bacteria.

Festering Bedsores

Kumarasamy’s curiosity spiked in 2008 when he realized he was dealing with something totally new. He reached out to Walsh, whose Cardiff lab was at the forefront of international antibiotic resistance research.

Around that time, Walsh was studying the case of a diabetic stroke patient of Indian origin. The man had festering bedsores and had been transferred from New Delhi to his home in Sweden for treatment. When bacteria cultured from his urine and feces evaded more than a dozen drugs, including last-resort carbapenems, Christian G. Giske, a clinical microbiologist at Stockholm’s Karolinska University Hospital, sent the samples to Walsh’s lab.

Stockholm Hotel

In a hotel room in the Swedish capital, Walsh and Giske named the gene that made the bacteria immune to virtually all these antibiotics New Delhi metallo-beta-lactamase-1.

Beta-lactams are a class of antibiotics that includes penicillins, cephalosporins and carbapenems. Beta-lactamase is an enzyme that destroys those drugs. Metallo-beta-lactamases are so named because they contain zinc and destroy carbapenems, the most powerful beta-lactams.

Kumarasamy, suspecting something similar in his own specimens, asked Walsh to share the DNA sequence of this new bacterial gene. Walsh did — and Kumarasamy got a match.

Kumarasamy began visiting Chennai hospitals anew to look for drug-resistant specimens. He also got samples from researchers in India’s northern Haryana state.

When his collection was added to those Walsh and his colleagues were studying, the researchers discovered the same NDM-1 gene from four countries: India, Pakistan, Bangladesh and the U.K. For most of the British patients, the link was recent travel to India or neighboring Pakistan.

In Kumarasamy’s samples from inside India, many cases emerged in people who hadn’t recently been hospitalized. That suggested the bacteria were spreading in the community.

‘Unsung Hero’

“He is India’s unsung hero,” Walsh says.

The University of Madras initially thought so, too. It feted Kumarasamy after he became the youngest scholar from the 155-year-old institution to have research appear in any publication of the British medical journal “The Lancet.” His August 2010 paper, in “The Lancet Infectious Diseases,” became that publication’s most-read article that year.

The mood soured a few days later. Officials at India’s Ministry of Health & Family Welfare balked at the gene’s name, which threatened medical tourism’s public image.

“There was a lot of stress and tension, and I could not sleep properly for two months,” says Kumarasamy, who says he developed gastric reflux and heartburn.

The next month, authorities at the ministry grilled the eight Indian contributors to the “Lancet” report, including lead author Kumarasamy, according to two co-authors who declined to be identified because their employers don’t permit them to speak to the media.

‘Batten Down the Hatches’

Officials questioned their data and chastised them for sending specimens overseas without approval, saying the researchers had violated a 13-year-old regulation, according to two in the group.

The Indian Council of Medical Research says it requires researchers to submit detailed proposals to send any bacterial collections abroad. The process may take at least four months.

“The regulations were already in place,” says Sandhya Visweswariah, a professor at the Indian Institute of Science in Bangalore.

The researchers countered that the rules were nebulous and were rarely enforced.

“It is suppression of scientific freedom,” Walsh says of the government behavior. “They just try to batten down the hatches and make everything very, very difficult and pretend nothing has happened.”

Front-Page News

After front-page stories on the superbug appeared in Indian newspapers, the government formed an antibiotic resistance task force. It recommended in April 2011 that antibiotic use be tracked in the country’s 100,000 hospitals to find excessive prescribing. The group advised making it harder to get antibiotics without a prescription by requiring pharmacists to keep records for two years to aid audits and inspections.

Current rules make a prescription mandatory, but regulations are rarely enforced and it’s easy to get potent antibiotics, even intravenous ones, without a doctor’s assent. The group advised enacting rules allowing drug inspectors to immediately cancel the license of pharmacists dispensing unprescribed antibiotics.

Task force member Ganguly says tracking antibiotic use will be difficult.

“How do you regulate 1.2 billion people with so much diversity?” he asks.

Dying Babies

While Kumarasamy was documenting NDM-1 in Chennai hospitals, pediatrician Vipin Vashishtha was discovering how deadly the gene can be.

In June 2010, new father Sanjeev Thakran, 28, rushed his half-hour-old son in a car through monsoon-soaked streets to Vashishtha’s Mangla Children’s Hospital in Bijnor. His wife, Lalita, had delivered baby Tapas in a maternity hospital across town three weeks early, and the infant was laboring for air.

Nurses in green scrubs warmed the 4-pound (1.8-kilogram) newborn in a dome-covered crib and fed him milk and medicines through a nasal tube. About 2 feet away, a frail-looking baby was connected to a ventilator, Sanjeev Thakran says.

Vashishtha, seated on a leather swivel chair in his consulting room, recalls thinking that Tapas might need only a few days of intensive care. Instead, the baby spent weeks in and out of the unit. Blood sometimes trickled from his nose and shriveling umbilicus, according to medical records.

Even though he was being treated with a carbapenem, the most powerful class of antibiotic, bacteria raged inside his tiny lungs and bloodstream, eventually attacking membranes covering his brain and spinal cord.

Incurable Scourge

Other infants in the eight-crib neonatal intensive care unit were suffering, too. Vashishtha, 48, had tried several antibiotics without success. When carbapenems didn’t work, he says, he felt helpless because he knew he was dealing with a potentially incurable scourge.

Tapas died 11 weeks after he was admitted. Lab results identified the culprit a month later: NDM-1. The gene was in bacteria known as Klebsiella pneumoniae. The germ exists in people’s gastrointestinal tract and can cause pneumonia and urinary-tract infections in hospital patients.

The lab also found two soil-borne species that normally cause trivial infections but that were suddenly becoming killers.

Tapas was one of 14 infants at the hospital who were infected with NDM-1-containing bacteria over the course of 17 months. Six of the babies died. Among the eight survivors, half developed meningitis, arthritis or water on the brain, Vashishtha wrote to an Indian medical journal in February 2011.

‘Horrific Period’

“It was the most horrific period,” Vashishtha says as he fixes his eyes on the playpen where he amuses children in his office. “I was losing neonates at regular intervals. I suspected we were dealing with something quite different, something quite new.”

Vashishtha says he has improved infection control, walling off part of the ICU for contagious, complicated cases.

He can’t, however, control what happens outside his hospital. Sewage from nearby homes flows in an open drain along one wall of the two-story building.

Bijnor, like other small cities in Uttar Pradesh, lacks a modern underground drainage system. During the rainy season, it’s impossible not to wade through sewage water, the doctor says.

‘Wash Hands Properly’

So far, Vashishtha has prevented more NDM-1 deaths. He fumigates his wards every four weeks and applies fresh paint every three months. He keeps hand-sanitizing liquid in his office, along the corridors and next to every bed in intensive care. Nurses must wash their hands with running water and soap and scrub with an antimicrobial sanitizer before handling patients.

“The first and foremost step to avoiding hospital-acquired infection is to wash hands properly,” he says.

India’s major hospitals are marshaling tactics from common cleanliness to computerized databases to outsmart resistant bacteria and prevent more tragedies.

Artemis Health Institute, a private, 300-bed specialty hospital in Gurgaon, southwest of New Delhi, employs an infection-control officer who collects data every month on the hospital’s four most troublesome bacteria to review patterns of drug resistance. The officer, Namita Jaggi, also serves as national secretary of a Buenos Aires-based group that collates infection information worldwide.

‘Infection Surveillance 24/7’

About 3 miles (4.8 kilometers) away, cardiac surgeon Naresh Trehan’s medical complex, Medanta-The Medicity, requires patients transferring from other hospitals to be screened for resistant bacteria. This procedure, routine in some Nordic countries, isn’t standard in India.

Medanta has a strict hand-washing policy and a 40-member team to monitor infections, says Trehan, 65, who trained in cardiac surgery at New York University and worked at Bellevue Hospital in Manhattan before returning to India in 1988.

“We have a very senior person whose sole responsibility is to keep the whole hospital under infection surveillance 24/7,” he says.

Livermore at the U.K.’s Health Protection Agency says these efforts may not be enough in a country where 626 million people defecate in the open and that treats only 30 percent of the 10.1 billion gallons of sewage generated each day. Even the most modern hospitals can’t exist as islands of cleanliness, he says.

“How does the hospital — however good its surgeons and physicians — isolate itself when its patients, staff and food all come from outside, where they are exposed to this soup of resistance?” he asks.

‘Hope for the Future’

Bush, the antibiotics researcher, has been investigating novel ways to fight bacteria since 1977. She says combinations of existing drugs, including an experimental compound from AstraZeneca in late-stage patient studies, may neutralize some carbapenem-destroying enzymes.

Should these mixtures pan out, they may help the superdrugs regain at least some of their potency, potentially extending their usefulness for a decade or more, she says.

A drug candidate from Basel, Switzerland-based Basilea Pharmaceutica AG (BSLN) in early-stage trials shows some promise against NDM-1, she says.

“What’s frustrating is to see that companies refused to address the issue until the last few years,” Bush says. “There are still some that are trying, and that’s the hope for the future.”

‘Very Cautious’

Drugs that could once again tackle the world’s most resistant germs would be a relief for people worldwide, Norway’s Skaret among them. She spent more than six months fearing a microbial time bomb until she learned that the NDM-1 supergerms had passed from her system.

Even though she escaped physical harm, Skaret says, NDM-1 made her feel isolated. She says therapists, concerned about their own exposure, refused to help her with rehabilitation to recover from the car accident. Neighbors who delivered food were careful not to get too close.

“When they heard about it, they were very cautious,” she says.

If Walsh’s projection is accurate, 100 million Indians may be carrying the NDM-1 gene unwittingly and doing little to contain its spread. The number of countries reporting NDM-1 will continue to grow as more bacteria pick up the gene and people transport it around the globe.

To prevent a worldwide catastrophe, microbiologists Kumarasamy and Walsh — along with scores of scientists and doctors inside and outside India — are sounding an alarm.

“Combine sophisticated medicine, poor sanitation and heavy antibiotic usage, and you have a rocket fuel to drive the accumulation of resistance,” Livermore says. “That surely is what India has created.”

 

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112 Responses to “Drug Resistant Bacteria”
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  1. Lily
    1 | May 8, 2012 3:17 pm

    There are always exceptions to the rule. I cannot just catch a cold. If I catch a cold I always, always go straight into a secondary infection. Every single time. Of course I know the difference between infection and no infection.


  2. My 2 Cents
    2 | May 8, 2012 3:20 pm

    Oh for goodness sakes… and all this time I thought your name “coldwarrior” referred to fighting communists, not viruses! My bad. Heh. :)


  3. Lily
    3 | May 8, 2012 3:23 pm

    @ My 2 Cents:

    LOL! Yeah CW now your name stands for a warrior of two different types of battles.
    /Just teasing you! ;)


  4. coldwarrior
    4 | May 8, 2012 3:24 pm

    @ My 2 Cents:

    :lol:

    i wish i could defeat this cold i have now!


  5. coldwarrior
    5 | May 8, 2012 3:32 pm

    @ Lily:

    once the lungs get all stuffed up from the cold, the bacteria have a nice, warm, dark, anaerobic place to live.

    prophylactic albuterol (puffer) works great to prevent that route of sickness


  6. Lily
    6 | May 8, 2012 3:37 pm

    @ coldwarrior:

    They did a bunch of tests on me to find out why …. my immune system seems to crap out on me if I get a cold. I go straight into sinus infection and lung infection. The treatment to correct is real expensive and since it is only affecting me when I get colds I am not a candidate for the treatment. I’ve had sinus surgery the works … but still if I get a cold I get very, very sick with infection. Fun, fun for me.


  7. Lily
    7 | May 8, 2012 3:38 pm

    @ coldwarrior:

    Yeah the puffer doesn’t help at least for me.


  8. coldwarrior
    8 | May 8, 2012 3:43 pm

    @ Lily:
    @ Lily:

    that will happen.


  9. Lily
    9 | May 8, 2012 3:46 pm

    @ coldwarrior:

    When my kids were in school it was hell on me. Since they aren’t in school and one has moved out … it is better. My hubby brought a nasty cold home to me during Christmas and in March another one. So I am still battling the remnants of my cough though getting better. But damn. Oh and I know to take my meds to the last pill or I will re-lapse.


  10. yenta-fada
    10 | May 8, 2012 4:00 pm

    coldwarrior wrote:

    @ My 2 Cents:

    i wish i could defeat this cold i have now!

    Over the years fighting lots of infections, I have at least two frontline defenses against them. One is Silversol, a form of nano-silva I buy from vitacost.com. It kills off several types of infections. I’ve used it orally, for my sinuses, ears, eyes, to disinfect surfaces, and the gel form for skin problems. American Biotech Labs has considerable research available online. It’s in the process of getting FDA certification which probably means it will go to prescription and get more expensive. It is amazing. No side effects like with massive doses of colloidal silver. The latter problem is overstated, imo.

    The second thing is (yuk) oil of oregano. I take it under the tongue, a few drops at a time. It’s strong and gross tasting, but I find it pretty effective if I’m fighting any infection. It’s too strong to be used for any other reason imo.

    I would not be without those!!
    btw, I was advised by a friend who used to be a nurse in a cystic fibrosis unit to use the nanosilver in a small home nebulizer to help clear a lung infection that lingered. It really did help.


  11. coldwarrior
    11 | May 8, 2012 4:00 pm

    if anything is taken from this post is that everyone should wash their hands more than they do.

    proper hand washing with regular soap and warm water is the best defense.


  12. Lily
    12 | May 8, 2012 4:02 pm

    @ coldwarrior:

    Oh gosh indeed. Always wash your hands. Grocery carts hold a lot of infections and virus’s ….


  13. coldwarrior
    13 | May 8, 2012 4:02 pm

    @ yenta-fada:

    silver works when used sparingly.

    i mix oil of oregano with tea tree oil in aloe vera gel as an antiseptic. works great.

    have heard of oregano oil under the tongue…WOW, that has to be strong.


  14. yenta-fada
    14 | May 8, 2012 4:03 pm

    @ Lily:

    Send me an email about the nano-silver, and I will give you any details you want.


  15. coldwarrior
    15 | May 8, 2012 4:03 pm

    Lily wrote:

    @ coldwarrior:
    Oh gosh indeed. Always wash your hands. Grocery carts hold a lot of infections and virus’s ….

    dont overuse hand sanitizers tho…use those only when you cant wash your hands. as said in the post:

    “Did you ever see the commercial for the hand sanitizers or Lysol? 99% of germs killed! Yeah, well the 1% that lived can now take a jacuzzi in your hand sanitizer while drinking Lysol cocktails at happy hour, so make sure you don’t ingest them!”


  16. Lily
    16 | May 8, 2012 4:04 pm

    @ yenta-fada:

    Sure will do. Does it affect the colon in any way shape or form??


  17. Lily
    17 | May 8, 2012 4:06 pm

    @ coldwarrior:

    Always use soap and water. Soap and water is the best route.


  18. 18 | May 8, 2012 4:06 pm

    I can’t help but think that, at some level, we’re far to antiseptic and sterile in the US and our immune system is far too undeveloped.


  19. yenta-fada
    19 | May 8, 2012 4:07 pm

    coldwarrior wrote:

    @ yenta-fada:
    silver works when used sparingly.
    i mix oil of oregano with tea tree oil in aloe vera gel as an antiseptic. works great.
    have heard of oregano oil under the tongue…WOW, that has to be strong.

    For some reason, tea tree oil is something I react badly to. Yes, the oregano is strong, but you become accustomed to using it over time. At least I did. The stuff is marvelous. I use a lot of this form of silver and have for about 4 years. Only when I need it, of course. NO SIDE EFFECTS ever. If my husband gets sick, I spray the air around me and stay away from him for a few days. It’s really worked and I have a compromised immune system.


  20. 20 | May 8, 2012 4:08 pm

    “Fecal veneer” Lovely. I don’t think I want to visit India, well, ever under the circumstances…


  21. yenta-fada
    21 | May 8, 2012 4:09 pm

    Lily wrote:

    @ yenta-fada:
    Sure will do. Does it affect the colon in any way shape or form??

    No, it is a disinfectant, but wouldn’t wipe out the good bacteria in the gut. However it works, it doesn’t have the side effects of an antibiotic. I’m sure if CW looked at the literature, he would understand how nanosilver works at the cellular level.


  22. yenta-fada
    22 | May 8, 2012 4:10 pm

    coldwarrior wrote:

    if anything is taken from this post is that everyone should wash their hands more than they do.
    proper hand washing with regular soap and warm water is the best defense.

    I’ve been told the same thing by the wife of an internationally known microbiologist.


  23. Calo
    23 | May 8, 2012 4:10 pm

    Drive By Comment

    This means that unlike previous germ-altering genes, NDM-1 can infiltrate dozens of bacterial species. Intestine-dwelling E. coli, the most common bacterium that people encounter, soil-inhabiting microbes and water-loving cholera bugs can all be fortified by the gene.

    In Kumarasamy’s samples from inside India, many cases emerged in people who hadn’t recently been hospitalized. That suggested the bacteria were spreading in the community.

    100 million Indians may be carrying the NDM-1 gene unwittingly and doing little to contain its spread.

    I saw this article on Drudge this morning and quickly scanned it.

    Scary stuff.


  24. Lily
    24 | May 8, 2012 4:11 pm

    @ Iron Fist:

    Turkey is just as bad. When my great-Aunt was in Turkey she said they were filthy people. Going to the bathroom just anywhere. But that was years and years ago. I’m sure it hasn’t changed much through the years.


  25. yenta-fada
    25 | May 8, 2012 4:12 pm

    MacDuff wrote:

    I can’t help but think that, at some level, we’re far to antiseptic and sterile in the US and our immune system is far too undeveloped.

    I think the average city dweller gets a lot of exposure to all kinds of disease. We have, with our huge third world immigrant population, exposure to diseases thought to have been eradicated. I do know what you mean though.


  26. Lily
    26 | May 8, 2012 4:16 pm

    @ yenta-fada:

    I think through cheap air travel and people coming from third world countries has greatly caused a problem. People maybe carrying a germ of some sort and not even know it. Thus 1 person can spread an illness or germ to many different people in different countries.


  27. yenta-fada
    27 | May 8, 2012 4:16 pm

    @ Calo:

    We have a very large Indian/Muslim population that go back and forth to their home countries all the time. They bring back the diseases with them. If I ever need to go to an emergency room, I take a facial mask and my nano silver.


  28. yenta-fada
    28 | May 8, 2012 4:18 pm

    @ Lily:

    Especially in Toronto, which is more like New York than most American cities due to the concentration of immigrant populations.


  29. coldwarrior
    29 | May 8, 2012 4:18 pm

    @ yenta-fada:

    it alters cell membranes, interferes with protein synthesis associated with ATP production

    (ATP=energy more or less)


  30. Lily
    30 | May 8, 2012 4:19 pm

    Tell me that bho isn’t hoping for riots in Chicago.

    Obama Pal Bill Ayers Calls On Students To Join Him In “Driving Out NATO” From Chicago…

    http://weaselzippers.us/2012/05/08/obama-pal-bill-ayers-calls-on-students-to-join-him-in-driving-out-nato-from-chicago/


  31. yenta-fada
    31 | May 8, 2012 4:20 pm

    Lily wrote:

    @ Iron Fist:
    Turkey is just as bad. When my great-Aunt was in Turkey she said they were filthy people. Going to the bathroom just anywhere. But that was years and years ago. I’m sure it hasn’t changed much through the years.

    Also, when economic problems re-emerge, the medical care deteriorates. It is extremely hard here to find a family physician if you don’t already have one. The system is swamped. So much for socialized medicine and accepting large numbers of so-called ‘refugees’.


  32. yenta-fada
    32 | May 8, 2012 4:21 pm

    coldwarrior wrote:

    @ yenta-fada:
    it alters cell membranes, interferes with protein synthesis associated with ATP production
    (ATP=energy more or less)

    Silver Sol interferes with protein synthesis???


  33. Lily
    33 | May 8, 2012 4:22 pm

    @ yenta-fada:

    I pray and hope obamacare is struck down by the Supreme Court. Their announcement cannot come soon enough.


  34. coldwarrior
    34 | May 8, 2012 4:24 pm

    yenta-fada wrote:

    coldwarrior wrote:
    @ yenta-fada:
    it alters cell membranes, interferes with protein synthesis associated with ATP production
    (ATP=energy more or less)
    Silver Sol interferes with protein synthesis???

    the positively charged silver ions do.

    that stuff works in the same way as antibiotics, more or less.


  35. 35 | May 8, 2012 4:24 pm

    @ Lily:

    Is it wrong for me to wish that some form of bodily harm, less than Death, is inflicted upon Bill Ayers?


  36. yenta-fada
    36 | May 8, 2012 4:25 pm

    I think WHO has become so politicized and influenced by big money investors in new drugs, that their once high standards are open to question.
    Dr.Donald Low, head of Public Health in Ontario is excellent. He did a great job during the SARS infection here a few years ago.


  37. yenta-fada
    37 | May 8, 2012 4:27 pm

    coldwarrior wrote:

    yenta-fada wrote:
    coldwarrior wrote:
    @ yenta-fada:
    it alters cell membranes, interferes with protein synthesis associated with ATP production
    (ATP=energy more or less)
    Silver Sol interferes with protein synthesis???
    the positively charged silver ions do.
    that stuff works in the same way as antibiotics, more or less.

    That’s interesting. I use fairly heavy doses when I need it, but otherwise don’t touch it unless I’m disinfecting a localized area and not inhaling much of it.


  38. citizen_q
    38 | May 8, 2012 4:28 pm

    Think I will swear off Indian food just to be safe.

    /


  39. yenta-fada
    39 | May 8, 2012 4:29 pm

    @ coldwarrior:

    The gel form of nanosilver is used for burns very widely.


  40. Lily
    40 | May 8, 2012 4:30 pm

    Not to mention if you are going to go to the trouble of washing your hands with soap and water …..dry with paper towels instead of a hand towel that has been used over and over.


  41. yenta-fada
    41 | May 8, 2012 4:30 pm

    Lily wrote:

    @ yenta-fada:
    I pray and hope obamacare is struck down by the Supreme Court. Their announcement cannot come soon enough.

    The Obama admin will pitch a fit. It will be ugly. Obamacare is wrong on so many levels.


  42. yenta-fada
    42 | May 8, 2012 4:31 pm

    citizen_q wrote:

    Think I will swear off Indian food just to be safe.
    /

    Radical. :-)


  43. Lily
    43 | May 8, 2012 4:32 pm

    @ Macker:

    No. Bill Ayers is influencing bho there is no doubt about it. None.
    He is wanting his vision from the 60′s realized through bho. There is no doubt at all about that.


  44. 44 | May 8, 2012 4:33 pm

    @ Lily:
    @ yenta-fada:

    16 TRILLION UPDINGS!


  45. Lily
    45 | May 8, 2012 4:34 pm

    @ yenta-fada:

    I hope they pitch a fit that will be so over the top that it will offend Americans of all stripes and I also hope the truth goes viral the real intentions of what obamacare is all about.


  46. RIX
    46 | May 8, 2012 4:35 pm

    Cell phones have done a lot to alleviate the common cold. Public phones are a hot bed of germs.
    I used to get off of a plane & head right for the phone.
    I had a lot more colds then.


  47. yenta-fada
    47 | May 8, 2012 4:35 pm

    coldwarrior wrote:

    @ yenta-fada:
    it alters cell membranes, interferes with protein synthesis associated with ATP production
    (ATP=energy more or less)

    I find it so effective that I wouldn’t stop using it. There’s always some little trade off. I have an autoimmune disease and the nanosilver has made a big difference in warding off bad infections.


  48. Lily
    48 | May 8, 2012 4:46 pm

    Lily wrote:

    Tell me that bho isn’t hoping for riots in Chicago.

    Obama Pal Bill Ayers Calls On Students To Join Him In “Driving Out NATO” From Chicago…

    http://weaselzippers.us/2012/05/08/obama-pal-bill-ayers-calls-on-students-to-join-him-in-driving-out-nato-from-chicago/

    Bill Ayers: The opposite of moral is not immoral but indifference???
    /this man is immoral and evil.


  49. yenta-fada
    49 | May 8, 2012 4:50 pm

    @ Lily:

    Yep. He is proactively evil.


  50. 50 | May 8, 2012 4:53 pm

    @ coldwarrior:

    So, anything important happen while I was off interviewing with Carter Penley for a Job?


  51. RIX
    51 | May 8, 2012 4:54 pm

    Ayers is trying to relive the 60s. He ws a punk then,
    now he is a silly old fool


  52. Lily
    52 | May 8, 2012 4:58 pm

    @ RIX:

    I do not know why anyone would listen to this anti-American. He goes on he was born when we nuked Japan. He is against nuclear weapons. But in his book he would like to see 25 million Americans dead.
    I find this a HUGE dis-connect.


  53. 53 | May 8, 2012 4:59 pm

    RIX wrote:

    Ayers is trying to relive the 60s. He ws a punk then,
    now he is a silly old fool

    Ayers wasn’t even a punk, just a worthless sack of shit spoiled rich kid who couldn’t do anything right and got his fellow spoiled rich kid friends killed.


  54. Lily
    54 | May 8, 2012 5:00 pm

    @ doriangrey:

    Now he wants more kids killed by having them riot and kick Nato out of Chicago.
    /coward


  55. yenta-fada
    55 | May 8, 2012 5:08 pm

    doriangrey wrote:

    @ coldwarrior:
    So, anything important happen while I was off interviewing with Carter Penley for a Job?

    The golf guys you & CW talk about? Kewl.


  56. yenta-fada
    56 | May 8, 2012 5:11 pm

    Lily wrote:

    @ RIX:
    I do not know why anyone would listen to this anti-American. He goes on he was born when we nuked Japan. He is against nuclear weapons. But in his book he would like to see 25 million Americans dead.
    I find this a HUGE dis-connect.

    The very rich are, indeed, different. Money covers up a lot of mistakes/depravity that would pulverize the little people.


  57. 57 | May 8, 2012 5:12 pm

    yenta-fada wrote:

    doriangrey wrote:
    @ coldwarrior:
    So, anything important happen while I was off interviewing with Carter Penley for a Job?
    The golf guys you & CW talk about? Kewl.

    Yea, Carter manufactures the very best Golf Shafts on the Planet. He’s been out of the business for about 10 years, and trying to reenter it now. Sadly the State of California seems to be doing their damnedest to prevent that from happening.


  58. yenta-fada
    58 | May 8, 2012 5:16 pm

    @ doriangrey:

    How expensive is it to buy a Congresscritter? There must be a discount these days with the economy…..


  59. Da_Beerfreak
    59 | May 8, 2012 5:18 pm

    Macker wrote:

    @ Lily:
    Is it wrong for me to wish that some form of bodily harm, less than Death, is inflicted upon Bill Ayers?

    Probably. :evil:
    But then who really gives a rat’s ass what happens to that rat turd. :twisted:


  60. RIX
    60 | May 8, 2012 5:21 pm

    @ Lily:
    Ayers is a sick, evil cretin. he marries Bernadine Dohrn
    & doubles down on sick and evil.


  61. yenta-fada
    61 | May 8, 2012 5:22 pm

    International trading OUTSIDE of using the U.S. dollar. Using Chinese currency:

    Iran is accepting renminbi for some of the crude oil it supplies to China, industry executives in Beijing and Kuwait and Dubai-based bankers said, partly as a consequence of US sanctions aimed at limiting Tehran’s nuclear programme.

    Tehran is spending the currency, which is not freely convertible, on goods and services imported from China.

    Most of the oil that goes from Iran to China is handled by the Unipec trading arm of Sinopec, China’s second-largest oil company, and through another trading company called Zhuhai Zhenrong, the oil industry executives said.


  62. RIX
    62 | May 8, 2012 5:24 pm

    @ doriangrey:
    Ayers walked out of the courtroom & said, “Guilty as
    sin , but free as a bird.”
    I’m sure that his aquital hd nothing to do with
    being the son of Commonwealth Edison President, Thomas
    Ayers a friend of Richard J Daley./


  63. Da_Beerfreak
    63 | May 8, 2012 5:26 pm

    doriangrey wrote:

    yenta-fada wrote:
    doriangrey wrote:
    @ coldwarrior:
    So, anything important happen while I was off interviewing with Carter Penley for a Job?
    The golf guys you & CW talk about? Kewl.

    Yea, Carter manufactures the very best Golf Shafts on the Planet. He’s been out of the business for about 10 years, and trying to reenter it now. Sadly the State of California seems to be doing their damnedest to prevent that from happening.

    California is the ninth circle of business hell. :evil:


  64. Lily
    64 | May 8, 2012 5:31 pm

    @ doriangrey:

    Hope you get the job! :)


  65. Lily
    65 | May 8, 2012 5:37 pm

    RIX wrote:

    @ doriangrey:
    Ayers walked out of the courtroom & said, “Guilty as
    sin , but free as a bird.”
    I’m sure that his aquital hd nothing to do with
    being the son of Commonwealth Edison President, Thomas
    Ayers a friend of Richard J Daley./

    That is disgusting. He has sold his soul to evil and all that evil has been festering all these years. I truly hope he is extremely disappointed when that racial war does not explode like he and his cronies in conjunction with the White House hope it does. This is what I have to say about someone who is very comfortable with the evil he has around him.


  66. RIX
    66 | May 8, 2012 5:46 pm

    @ Lily:

    Dohrn was criticized for comments she made about the murders of actress Sharon Tate and retail store owners Leno and Rosemary LaBianca by the Charles Manson clan. In a speech during the December 1969 “War Council” meeting organized by the Weathermen, attended by about 400 people in Flint, Michigan, Dohrn said, “First they killed those pigs, then they ate dinner in the same room with them, then they even shoved a fork into the pig Tate’s stomach! Wild!”[14] In greeting each other, delegates to the war council often spread their fingers to signify the fork

    A marriage made in hell.


  67. Lily
    67 | May 8, 2012 6:07 pm

    @ RIX:

    Good night in Georgia! what evil on display. They are both disgusting evil people.
    /how could anyone say such a thing? Only someone so devoid of morals that a vacuum occured and what filled that vacuum was not something good.


  68. NoThreat2U
    68 | May 8, 2012 6:09 pm

    @ Lily:
    Good Evening {{{Lily}}}

    I am sitting here waiting for the evening news to return from commercial. Some story about not allowing gun sales for three days here in PA. Cant wait to hear what that is all about.


  69. RIX
    69 | May 8, 2012 6:11 pm

    @ Lily:
    And they are friends of the Obamas. BHO sat on boards
    with Ayers,launched his political career in Ayers
    front room & he and his wife Bernadine baby sat the Obama
    children.


  70. Lily
    70 | May 8, 2012 6:11 pm

    @ NoThreat2U:

    Evening {{{NT2U}}}! Hope this day finds feeling okay.
    I am sitting here waiting for a call from son so we can go visit the grandbaby!


  71. RIX
    71 | May 8, 2012 6:12 pm

    @ NoThreat2U:
    How are you feeling today?


  72. NoThreat2U
    72 | May 8, 2012 6:13 pm

    @ Lily:
    Actually my tummy is hurting. I have to keep getting up and lay on the couch all curled up…like now. Gonna try to come back later.


  73. NoThreat2U
    73 | May 8, 2012 6:14 pm

    @ RIX:
    I ate three french fries and they kicked my ass. lol lol


  74. Lily
    74 | May 8, 2012 6:17 pm

    RIX wrote:

    @ Lily:
    And they are friends of the Obamas. BHO sat on boards
    with Ayers,launched his political career in Ayers
    front room & he and his wife Bernadine baby sat the Obama
    children.

    Oh I know Dohrn and Aryers groomed bho. They are more than friends. They want the same thing. Racial war to break out here in the U.S.
    Yet this is not shouted from the rooftops. Also Valerie Jarrett is also connected with Dohrn, Aryers and bho. Jarrett is just as evil as the others they all have one common goal to destroy the Constitutional Republic of the United States. To reshape it in their view. This should be all red flags to all the media yet they are ignoring it. Not to mention all the un-elected czars bho has put in place. This should be of great concern to the American people.


  75. Da_Beerfreak
    75 | May 8, 2012 6:18 pm

    NoThreat2U wrote:

    @ Lily:
    Good Evening {{{Lily}}}
    I am sitting here waiting for the evening news to return from commercial. Some story about not allowing gun sales for three days here in PA. Cant wait to hear what that is all about.

    I have read elsewhere that the state of PA will be updating one of its main databases and they expect that work to take about 60 hours. Some Folks are making a big deal out of nothing.


  76. coldwarrior
    76 | May 8, 2012 6:18 pm

    yenta-fada wrote:

    coldwarrior wrote:
    @ yenta-fada:
    it alters cell membranes, interferes with protein synthesis associated with ATP production
    (ATP=energy more or less)
    I find it so effective that I wouldn’t stop using it. There’s always some little trade off. I have an autoimmune disease and the nanosilver has made a big difference in warding off bad infections.

    atp as in energy that that individual cell uses, not overall body atp produstion

    atp


  77. Lily
    77 | May 8, 2012 6:18 pm

    NoThreat2U wrote:

    @ RIX:
    I ate three french fries and they kicked my ass. lol lol

    Sorry to hear that. {{NT2U}} stay away from that type of food that hurts you!!!!!!


  78. coldwarrior
    78 | May 8, 2012 6:18 pm

    doriangrey wrote:

    @ coldwarrior:
    So, anything important happen while I was off interviewing with Carter Penley for a Job?

    i hit a 320yd drive with one of his shafts yesterday!

    (and i had 4 witnesses!!!!)

    good luck!


  79. citizen_q
    79 | May 8, 2012 6:19 pm

    @ RIX:
    And don’t forget chairman owe-bama lied about his relationship with ayers. Just like he lied about rev. wright. It’s a challenge to figure out who is the worst scumbag among the demon-craps.

    @ NoThreat2U:
    I hope you feel better.


  80. RIX
    80 | May 8, 2012 6:19 pm

    @ NoThreat2U:
    Sorry to hear that.


  81. coldwarrior
    81 | May 8, 2012 6:22 pm

    doriangrey wrote:

    Yea, Carter manufactures the very best Golf Shafts on the Planet. He’s been out of the business for about 10 years, and trying to reenter it now.

    wooohooo!!!!

    (and i am getting new clubs in the spring….better really start saving my pennies)


  82. RIX
    82 | May 8, 2012 6:24 pm

    @ Lily:
    Obama called Ayers “Just a guy in the neighborhood”
    when he was trying to get some distance.
    And the Media just said a collective “Good enough for me.”
    Jarrett is the one who recruited Van Jones.
    It is a nasty, radical cabal, but they are awash with
    money.


  83. RIX
    83 | May 8, 2012 6:26 pm

    @ citizen_q:

    @ RIX:
    And don’t forget chairman owe-bama lied about his relationship with ayers. Just like he lied about rev. wright. It’s a challenge to figure out who is the worst scumbag among the demon-craps.

    Obama gets away with the lies, because the last thing that
    the MSM wants is the truth.


  84. RIX
    84 | May 8, 2012 6:27 pm

    Later Gators. Everybody have a great evening.


  85. waldensianspirit
    85 | May 8, 2012 6:31 pm

    This is how it is done.

    Americans shall have free press. Doesn’t mean our enemies have the freedom to propagandise.


  86. huckfunn
    86 | May 8, 2012 6:35 pm

    Speaking of drug resistant germs, here’s Joe being Joe. The guy is a complete embarrassing disgrace.
    Biden To Rabbis: ‘It was our fault.’


  87. brookly red
    87 | May 8, 2012 6:36 pm

    yenta-fada wrote:

    @ doriangrey:

    How expensive is it to buy a Congresscritter? There must be a discount these days with the economy…..

    just the opposite the reason the economy is so bad is because they are so expensive.


  88. waldensianspirit
    88 | May 8, 2012 6:39 pm

    @ huckfunn:
    Gee, he growls


  89. huckfunn
    89 | May 8, 2012 6:41 pm

    waldensianspirit wrote:

    @ huckfunn:
    Gee, he growls

    I hope BO-hole keeps Biden front and center for the next 6 months.


  90. waldensianspirit
    90 | May 8, 2012 6:42 pm

    John Kerry Joins The McRINO Brigade, Calls For Arming Syrian Rebels…

    Unfreaking real! Has tfk seen this?


  91. citizen_q
    91 | May 8, 2012 6:42 pm

    @ huckfunn:
    Dumb and arrogant is no way to go through life son — Dean Warner Animal house


  92. huckfunn
    92 | May 8, 2012 6:49 pm

    citizen_q wrote:

    @ huckfunn:
    Dumb and arrogant is no way to go through life son — Dean Warner Animal house

    It’s a toss-up as to which is goofier; Biden’s obtuse bloviating or Carney’s lame-ass efforts to clean up after him. Reminds me of a Jerry Lewis -- Dean Martin routine.


  93. waldensianspirit
    93 | May 8, 2012 6:57 pm

    @ huckfunn:
    With no Goldie Hawn to lighten the mood with her laugh. All they got are sour womyn like Pelosi


  94. citizen_q
    94 | May 8, 2012 6:58 pm

    huckfunn wrote:

    citizen_q wrote:
    @ huckfunn:
    Dumb and arrogant is no way to go through life son — Dean Warner Animal house

    It’s a toss-up as to which is goofier; Biden’s obtuse bloviating or Carney’s lame-ass efforts to clean up after him. Reminds me of a Jerry Lewis – Dean Martin routine.

    Or at least the Jim Care movie Dumb and Dumber.


  95. citizen_q
    95 | May 8, 2012 7:02 pm

    waldensianspirit wrote:

    @ huckfunn:
    With no Goldie Hawn to lighten the mood with her laugh. All they got are sour womyn like Pelosi

    aka The Wicked Witch Of The West.


  96. waldensianspirit
    96 | May 8, 2012 7:06 pm

    @ citizen_q:
    Pelosi’s year book picture could’ve made me(if in her college circles) make a lifetime mistake. *Shudder*


  97. huckfunn
    97 | May 8, 2012 7:08 pm

    @ waldensianspirit:
    @ citizen_q:
    When the dims were trying to decide who would be Obammy’s running mate for the 2008 election, a liberal friend of mine said that Joe Biden might be a good choice. I replied “Yes, please. Joe Biden would be perfect”. He hasn’t disappointed.


  98. citizen_q
    98 | May 8, 2012 7:09 pm

    @ waldensianspirit:
    She’s had so many face lifts her navel could pass for a third nipple.


  99. citizen_q
    99 | May 8, 2012 7:16 pm

    @ huckfunn:
    So true, and a tribute the MFM’s malfeasance that biden and obama have not been laughed out of town.

    SNL alone could fire most of its writing staff. Biden’s material practically writes itself and obama is not far behind. Not to mention that rat fink reid, or we have to pass the bill to find out what’s in it pelosi herself.


  100. NoThreat2U
    100 | May 8, 2012 7:35 pm

    @ Da_Beerfreak:
    Yeah, the State Police fingerprint system. Just wanted to make sure it wasn’t something stupid.


  101. NoThreat2U
    101 | May 8, 2012 7:36 pm

    @ Lily:
    Lily I am still working on what foods I can handle and which ones I cant.


  102. NoThreat2U
    102 | May 8, 2012 7:38 pm

    @ citizen_q:
    @ RIX:
    It’s OK gentlemen. It is what it is and we all have our own individual crosses to bear. I will be fine :)


  103. brookly red
    103 | May 8, 2012 7:55 pm

    OK it is a slow night. I don’t usually post this kind of thing but I so angry that I must.

    http://www.foxnews.com/us/2012/05/07/beating-suspect-could-face-additional-charges-in-wwii-vet-death/?test=latestnews

    even now I have a hard time supporting the death penalty but stuff like this makes me consider it.


  104. NoThreat2U
    104 | May 8, 2012 8:02 pm

    @ brookly red:
    He deserves nothing less then death. I dont wanna hear about his sucky childhood and dumb shit like that either. He made a choice to beat and rape an elderly woman. Fry his ass.


  105. huckfunn
    105 | May 8, 2012 8:05 pm

    @ brookly red:
    @ NoThreat2U:
    O’Reilly has a piece right now on how blacks are treated differently by the MFM and politicians.


  106. brookly red
    106 | May 8, 2012 8:06 pm

    NoThreat2U wrote:

    @ brookly red:
    He deserves nothing less then death. I dont wanna hear about his sucky childhood and dumb shit like that either. He made a choice to beat and rape an elderly woman. Fry his ass.

    I am equally as outraged that this only made the news after a British paper ran it…


  107. coldwarrior
    107 | May 8, 2012 8:08 pm

    new thread, peeps…yinz are making me use my trackball too much to keep up

    :lol:


  108. NoThreat2U
    108 | May 8, 2012 8:08 pm

    @ brookly red:
    That’s because here it would have screwed up the narrative about the innocent Trayvon and the “white Hispanic” who was racist enough to shoot the little sweetheart.


  109. Lily
    109 | May 8, 2012 8:10 pm

    @ NoThreat2U:

    Stay away from rich and fried foods would be my first guess. I have gall bladder problems and this has worked for me…so far. At least until I can get well enough for surgery.


  110. brookly red
    110 | May 8, 2012 8:12 pm

    huckfunn wrote:

    @ brookly red:
    @ NoThreat2U:
    O’Reilly has a piece right now on how blacks are treated differently by the MFM and politicians.

    OK, I live in the inner city & I am no stranger to crime & who does what to whom. But The fact that this little gem was ignored by the media (including Fox) while the whole Zimmerman thing is going down is really pushing my envelope.


  111. Lily
    111 | May 8, 2012 8:14 pm

    @ brookly red:

    Predators when they are young prey on the old and weak…no excuse for this horrid behavior. This was more than just a home invasion. This was to rape and blunder. 1st degree murder with special circumstances period. Their lives were worth a car. Disgusting.


  112. Lily
    112 | May 8, 2012 8:16 pm

    @ brookly red:

    20 years old. A beginning psychopath period. If they wouldn’t have caught him he would have had more victims in his wake.


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