Good morning all! Welcome to Grand Rounds here at Blogmocracy General Hospital. There is fresh coffee and bagels in the back of the room, help yourselves. Our grad-ass CJ will be more than happy to toast your bagels for you. Please hit his tip jar.
This topic is most concerning because tuberculosis is highly contagious and normally can only be cured after months of intense anti-biotic therapy. This MDR-TB (multiple drug resistant tuberculosis) has been around for a while, now there is totally drug resistant TB. The link below goes to the main article at the CDC. It is rather lengthy so I wont post it here. Do go over and have a read.
Factors driving the increase in drug-resistant tuberculosis (TB) in the Eastern Cape Province, South Africa, are not understood. A convenience sample of 309 drug-susceptible and 342 multidrug-resistant (MDR) TB isolates, collected July 2008–July 2009, were characterized by spoligotyping, DNA fingerprinting, insertion site mapping, and targeted DNA sequencing. Analysis of molecular-based data showed diverse genetic backgrounds among drug-sensitive and MDR TB sensu stricto isolates in contrast to restricted genetic backgrounds among pre–extensively drug-resistant (pre-XDR) TB and XDR TB isolates. Second-line drug resistance was significantly associated with the atypical Beijing genotype. DNA fingerprinting and sequencing demonstrated that the pre-XDR and XDR atypical Beijing isolates evolved from a common progenitor; 85% and 92%, respectively, were clustered, indicating transmission. Ninety-three percent of atypical XDR Beijing isolates had mutations that confer resistance to 10 anti-TB drugs, and some isolates also were resistant to para-aminosalicylic acid. These findings suggest the emergence of totally drug-resistant TB.